Job Description for a Postdoctoral Research Fellow in Zeng’s Laboratory
We are recruiting a highly self-motivated, intelligent, and hard-working postdoctoral research fellow to do research in the area of induction of immune tolerance in allogeneic hematopoietic cell transplantation (HCT). In particular, the focus will be on revealing the mechanisms of acute and chronic graft versus host disease (GVHD), which may involve the role of Th1, Th2, Th17, post-mitotic T memory stem cells, natural killer T cells, and Foxp3 Treg cells, as well as tissue expression of co-inhibitory molecules (i.e. B7-H1 and B7H4). Applicants should have PhD or MD/PhD in Immunology, Hematology, Biology, or Biochemistry. Research experience in HCT or transplantation tolerance is a plus but not required. Our laboratory is in the Departments of Hematology/Hematopoietic cell transplantation and Diabetes Research, The Beckman Research Institute, City of Hope National Medical Center. The HCT program at City of Hope is the second largest program in USA. The islet transplantation program at City of Hope is the fourth largest program in USA. If you want to know more about Zeng’s lab, please check at ww***org[点击查看]@coh.org.
Recent lab publications:
1.Y. Liang, T. Huang, C. Zhang, I.Todorov, M. Atkinson, F. Kandeel, S. Forman, and D. Zeng. Donor CD8 T cells facilitate induction of chimerism and tolerance without causing GVHD in NOD mice conditioned with anti-CD3 mAb. Blood, 2005, 105: 2180-2188.
2.Zhang C, I. Todorov. Z. Zhang, Y. Liu, F. Kandeel, S. Forman, S. Strober, and D. Zeng. Zhang C, I. Todorov. Z. Zhang, Y. Liu, F. Kandeel, S. Forman, S. Strober, and D. Zeng. Donor CD4 T and B Cells in Transplants Induce Chronic Graft versus Host Disease with Autoimmune Manifestations. Blood, 2006;107:2993-3001.
(There was a commentary about this paper; Judith A Shizuru: Of mice and men Blood 107: 2589)
3.Zhang C., J. Lou, N. Li, I. Todorov, C. Lin, Y. Cao, C. Contag, F. Kandeel, S. Forman, and D. Zeng. Donor CD8 T cells mediate GVL without GVHD in recipients conditioned with Anti-CD3 mAb. J. Immunol. 2007, 178:838-850.
4.Zhang, C., I. Todorov, C. Lin, M. Atkinson, F. Kandeel, S. Forman, and D. Zeng. Elimination of insulitis and augmentation of islet β cell regeneration via induction of chimerism in overtly diabetic NOD mice. PNAS, 2007; 104:2337-2342.
(This paper was selected by Leonard Harrison into Faculty of 1000 Biology, 15 May 2007 ww***com[点击查看])
5.Li, N., D. Zhao, M. Kirschbaum, C. Zhang, C. Lin, I. Todorov. F. Kandeel, S. Forman, and D. Zeng. HDAC Inhibitor SAHA Reduces Cytokine Storm and Facilitates Induction of Chimerism that Reverses Lupus in Anti-CD3 Conditioning Regimen. PNAS, 2008; 105:4796-4801.
6.Zhao, D., T. Yi, C. Zhang, C. Lin, F. Kandeel1, S. Forman, and D. Zeng. In vivo activated CD103 CD4 regulatory T cells ameliorate on-going chronic GVHD (Blood, 2008,112: 2129-2138).
7.Yi, T., D. Zhao, C. Zhang, T. LeBon, F. Kandeel, S. Forman, and D. Zeng. Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated Acute Graft versus Host Diseases (Blood, 2008,112: 2101-2110).
8.Li, N., Y. Chen, W. He, T. Yi, D. Zhao, C. Zhang, C. Lin, F. Kandeel, S. Forman, D. Zeng. Anti-CD3-preconditioning separates graft-versus-leukemia from graft-versus-host-disease via modulating host dendritic cell and donor T cell migration in TBI-conditioned recipients. (Blood, 2009, 113: 953-962).
9.Yi, T., D. Zhao, J. Young, and D. Zeng. Reciprocal differentiation and tissue specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease. (Blood, 2009; 114:3101-3112).
(There was a commentary about this paper; Daniel Fowler: T cells helping GVHD: take-away lessons. Blood 114:2858. This paper was also introduced by Gerard Socie in Hematologist, November/December, 2009. This paper was selected by David Adams into Faculty of 1000 Medicine, 5 Aug 2009 f1***com[点击查看]
10.Wang, L., T. Yi, M. Kortylewski, Y. Iwakura, D. Pardoll, D. Zeng, and H. Yu (Zeng and Yu co-corresponding authors). IL-17 is pro-carcinogenic through an IL-6/Stat3 signaling pathway (J. Exp. Med. 2009; 206:1457-1464).
11.Zhang C., M. Wang, J. RacineI. Todorov, C. Lin, Y. Cao, M. Atkinson, and D. Zeng. Induction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes (Diabetes, 2010, under revision).
12.Yi, T., X. Li, Y. Chen, L. Wang, H. Johnston, H. Liu, S. Forman, L. Chen, D. Zeng. Host antigen presenting cells augment in vivo expansion of donor natural regulatory T cells via B7H1-B7.1 axis in allogeneic recipients (Blood, 2010, under revision).
13.Zhao, D., J. Young, Y. Chen, E. Shen, T. Yi, G. Du, P. Chu, and D. Zeng. Donor CD4 T cells that possess both Allo- and autoreactivity in transplants mediate chronic graft versus host disease (Manuscript in preparation).
14.He W., M. Kirschbaum, N. Li, T. Yi, H. Liu, S. Forman, and D. Zeng. Synergistic effect of anti-CD3 and Vorinostat in the prevention of acute GVHD and retention of GVL in a radiation-free conditioning regimen (Manuscript in preparation).
15.Racine, J., M. Wang, I. Todorov, and D. Zeng. Donor-derived APCs mediate deletion of host autoreactive T cells in the thymus of mixed-chimeric BDC2.5/NOD recipients (manuscript in preparation).
16.Young, J., Y. Chen, D. Zhao, and D. Zeng. Mutual activation of donor CD4 T and B cells in transplants play an initial role in the pathogenesis of chronic GVHD (Manuscript in preparation).
17.Li, X., T. Yi, L. Chen, and D. Zeng. Radiation-free anti-CD3-conditioning regimen maintains tissue protection mechanisms and prevents GVHD: Role of tissue expression of B7H1 (Manuscript in preparation).
PI information:
Dr. Defu Zeng had his postdoctoral training under Dr. Samuel Strober, a pioneer and world leader in transplantation immune tolerance at Stanford University School of medicine.
Dr. Zeng is currently an associate professor at Departments of Diabetes Research and Hematopoietic Cell Transplantation, The Beckman Research Institute, City of Hope National Medical Center. Dr. Zeng’s lab is highly productive, and he is well-known in the area of transplantation immune tolerance in USA. His lab is equivalent to an excellent lab at Stanford University or Harvard University. Dr. Zeng’s first PhD student Tangsheng Yi just joined Jayson Cyster’s lab, a world renowned Howard Hughs fellow lab, at UCSF to do his postdoctoral training. Now, his another two PhD students Jim Young and Jeremy Racine are aiming at Yale University and Harvard University for his postdoctoral fellow training in the near future.
Dr. Zeng is a reviewer for many journals including J. Experimental Medicine, J. Clinical Investigation, Blood, J. Immunology, Diabetes, J. Blood and Marrow transplantation; he is also an ad hoc member for NIH study sections including Transplantation, Tolerance, and Tumor (TTT), Hypersensitivity, Autoimmunity, and Immune-related Disease (HAI), and Cancer Immunology and Immunotherapy (CII). He is also a grant reviewer for Hong Kong Research Burau. Dr. Zeng was the section chair of GVHD for AAI 2009, and he is going to be an abstract reviewer for ASH 2010.
Dr. Zeng wants to recruit outstanding postdoctoral fellows and help them to succeed in career development in Immunology and/or transplantation, using hematopoietic cell transplantation as a model for study immune response and immune regulation. This model is as good as other autoimmune disease models such as type 1 diabetes, lupus, arthritis, and EAE.
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